Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health

Superoxide dismutase Superoxide dismutase

Corneal endothelial integrity in aging mice lacking superoxide dismutase-1 and/or superoxide dismutase-3

PURPOSE To evaluate the age-induced changes in corneal endothelial morphology in mice lacking the cytosolic copper-zinc superoxide dismutase (SOD-1), the interstitial extracellular superoxide dismutase (SOD-3), or both of these SOD isoenzymes. METHODS The central corneal endothelial morphologies of old C57BL-6J wild type (n=19), SOD-1 null (n=16), SOD-3 null (n=15), and SOD1/3 null (n=11) mic...

Health benefits of exercise.

How true! God never meant his machine to be mended by ordinary mortals. It was made with built in mechanisms needed for the rescue measures. Modern living has robbed most of the “civilised” world of the many benefits of an active lifestyle. Man has become sedentary what with all the gadgets for assisting him in every walk of life. Even housewives have become more or less sedentary. This is a cu...

Exercise Provides Direct Biphasic Cardioprotection via Manganese Superoxide Dismutase Activation

Epidemiologic investigations have shown that exercise reduces morbidity and mortality from coronary artery disease. In this study, using a rat model, we attempted to determine whether exercise can reduce ischemic injury to the heart and elucidate a mechanism for the cardioprotective effect of exercise. Results showed that exercise significantly reduced the magnitude of a myocardial infarction i...

Inhibitory effect of superoxide-generating quinones on superoxide dismutase.

The one-electron reduction of quinones to semiquinones and the subsequent autooxldatlon of the semlqulnone back to the quinone can generate large quantities of superoxide (0~) (1,2). This reductlon-oxldation process, known as redox cycling, is anion radical catalyzed by a variety of cellular flavoproteins and is thought to be responsible for many of the therapeutic and toxic effects of quinonoi...